La myogenèse (du grec myo "muscle" et genesis "naissance") est un phénomène biologique qui conduit à la formation des tissus musculaires. Elle a d'abord lieu lors du développement de l'embryon, puis lors de certains phénomènes de réparation (après déchirure musculaire par exemple).

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  • La myogenèse (du grec myo "muscle" et genesis "naissance") est un phénomène biologique qui conduit à la formation des tissus musculaires. Elle a d'abord lieu lors du développement de l'embryon, puis lors de certains phénomènes de réparation (après déchirure musculaire par exemple).
  • Myogenesis is the formation of muscular tissue, particularly during embryonic development.Muscle fibers form from the fusion of myoblasts into multi-nucleated fibers called myotubes. In the early development of an embryo these myoblasts will proliferate if enough fibroblast growth factor (FGF) is present. When the FGF runs out, the myoblasts cease division and secrete fibronectin onto their extracellular matrix.The second stage involves the alignment of the myoblasts into the myotubes. The identity of the myoblasts in this stage is not crucial. Studies have shown that even rat and chick myoblasts have aligned.The third stage is the actual cell fusion itself. In this stage, calcium ions are critical for development. Fusion is mediated by a set of metalloproteinases called meltrins. Myocyte enhancer factors (MEFs) promote myogenesis. Serum response factor (SRF) plays a central role during myogenesis, being required for the expression of striated alpha-actin genes. Expression of skeletal alpha-actin is also regulated by the androgen receptor; steroids can thereby regulate myogenesis.
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  • La myogenèse (du grec myo "muscle" et genesis "naissance") est un phénomène biologique qui conduit à la formation des tissus musculaires. Elle a d'abord lieu lors du développement de l'embryon, puis lors de certains phénomènes de réparation (après déchirure musculaire par exemple).
  • Myogenesis is the formation of muscular tissue, particularly during embryonic development.Muscle fibers form from the fusion of myoblasts into multi-nucleated fibers called myotubes. In the early development of an embryo these myoblasts will proliferate if enough fibroblast growth factor (FGF) is present. When the FGF runs out, the myoblasts cease division and secrete fibronectin onto their extracellular matrix.The second stage involves the alignment of the myoblasts into the myotubes.
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  • Myogenèse
  • Myogenesis
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