In enzymology, a glutamate–cysteine ligase (EC 6.3.2.2) is an enzyme that catalyzes the chemical reactionATP + L-glutamate + L-cysteine ADP + phosphate + gamma-L-glutamyl-L-cysteineThe 3 substrates of this enzyme are ATP, L-glutamate, and L-cysteine, whereas its 3 products are ADP, phosphate, and gamma-L-glutamyl-L-cysteine.This enzyme belongs to the family of ligases, specifically those forming carbon-nitrogen bonds as acid-D-amino-acid ligases (peptide synthases).

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dbpedia-owl:abstract
  • In enzymology, a glutamate–cysteine ligase (EC 6.3.2.2) is an enzyme that catalyzes the chemical reactionATP + L-glutamate + L-cysteine ADP + phosphate + gamma-L-glutamyl-L-cysteineThe 3 substrates of this enzyme are ATP, L-glutamate, and L-cysteine, whereas its 3 products are ADP, phosphate, and gamma-L-glutamyl-L-cysteine.This enzyme belongs to the family of ligases, specifically those forming carbon-nitrogen bonds as acid-D-amino-acid ligases (peptide synthases). The systematic name of this enzyme class is L-glutamate:L-cysteine gamma-ligase (ADP-forming). Other names in common use include gamma-glutamylcysteine synthetase, gamma-glutamyl-L-cysteine synthetase, and gamma-glutamylcysteinyl synthetase. This enzyme participates in glutamate metabolism and glutathione metabolism, it is the first enzyme in the glutathione biosynthesis pathway. Buthionine sulfoximine and [[S-Butyl-DL-homocysteine-[S,R]-sulfoximine]] are known to inhibit this enzyme.
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  • Glutamate-cystéine ligase
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  • In enzymology, a glutamate–cysteine ligase (EC 6.3.2.2) is an enzyme that catalyzes the chemical reactionATP + L-glutamate + L-cysteine ADP + phosphate + gamma-L-glutamyl-L-cysteineThe 3 substrates of this enzyme are ATP, L-glutamate, and L-cysteine, whereas its 3 products are ADP, phosphate, and gamma-L-glutamyl-L-cysteine.This enzyme belongs to the family of ligases, specifically those forming carbon-nitrogen bonds as acid-D-amino-acid ligases (peptide synthases).
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  • Glutamate-cystéine ligase
  • Glutamate–cysteine ligase
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