About: Simvastatin

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An Entity of Type : dbo:ChemicalSubstance, within Data Space : fr.dbpedia.org associated with source document(s)

Attributes	Values
rdf:type	Thing chemical compound Chemical compound dul:ChemicalObject dbo:ChemicalSubstance
rdfs:label	Simvastatine (fr) Simvastatin (de) Simvastatin (en) Simvastatin (sv) Simvastatine (nl) Simwastatyna (pl) Симвастатин (uk)
rdfs:comment	La simvastatine est une statine, c’est-à-dire un inhibiteur puissant de l'enzyme hydroxyméthylglutaryl CoA réductase — ou HMG-CoA réductase — (enzyme impliquée dans la biosynthèse du cholestérol). La simvastatine abaisse la concentration des triglycérides et augmente la dégradation du LDL-cholestérol. La simvastatine pourrait réduire la progression de la plaque d'athérome et donc la mortalité par accident cardiovasculaire. Comme certains inhibiteurs de L'HMG-CoA réductase sont tératogènes chez l'animal, la simvastatine est contre-indiquée pour la femme enceinte. (fr)
rdfs:seeAlso	http://echa.europa.eu/substance-information/-/substanceinfo/100.115.749 http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=2955 http://www.hmdb.ca/metabolites/HMDB0005007 https://commons.wikimedia.org/wiki/Category:Simvastatin https://tools.wmflabs.org/magnustools/cas.php?cas=79902-63-9 https://www.ncbi.nlm.nih.gov/sites/entrez?cmd=search&db=pccompound&term=%22RYMZZMVNJRMUDD-HGQWONQESA-N%22InChIKey http://toxnet.nlm.nih.gov/cgi-bin/sis/search2/r?dbs+hsdb:@term+@DOCNO+7208 http://www.whocc.no/atc_ddd_index/?code=C10AA01 http://www.drugbank.ca/drugs/DB00641 https://comptox.epa.gov/dashboard/DTXSID0023581 http://bioportal.bioontology.org/ontologies/RXNORM?p=classes&conceptid=36567 http://chemapps.stolaf.edu/jmol/jmol.php?&model=InChI=InChI=1S/C25H38O5/c1-6-25(4,5)24(28)30-21-12-15(2)11-17-8-7-16(3)20(23(17)21)10-9-19-13-18(26)14-22(27)29-19/h7-8,11,15-16,18-21,23,26H,6,9-10,12-14H2,1-5H3/t15-,16-,18+,19+,20-,21-,23-/m0/s1 http://chemapps.stolaf.edu/jmol/jmol.php?model=CCC(C)(C)C(=O)OC1CC(C=C2C1C(C(C=C2)C)CCC3CC(CC(=O)O3)O)C http://fdasis.nlm.nih.gov/srs/srsdirect.jsp?regno=AGG2FN16EV http://www.simolecule.com/cdkdepict/depict/bow/svg?smi=CCC(C)(C)C(=O)OC@H1CC@H(C=C2C@H1C@H(C@H(C=C2)C)CCC@@H3CC@H(CC(=O)O3)O)C&zoom=2.0&annotate=cip https://dtp.cancer.gov/dtpstandard/servlet/dwindex?searchtype=NSC&chemnameboolean=and&outputformat=html&searchlist=758706&Submit=Submit https://mor.nlm.nih.gov/RxNav/search?searchBy=NUI&searchTerm=N0000148200 https://ncim-stage.nci.nih.gov/ncimbrowser/ConceptReport.jsp?dictionary=NCI%20Metathesaurus&code=C0074554 https://www.patientslikeme.com/treatments/show/simvastatin
sameAs	Simvastatin Simvastatin Simvastatin Simvastatin Simvastatin Simvastatin Simvastatin Simvastatin Simvastatin Simvastatin Simvastatin Simvastatin Simvastatin Simvastatin Simvastatin Simvastatin Simvastatin Simvastatin Simvastatin Simvastatin Simvastatin Simvastatin Simvastatin Simvastatin Simvastatin Simvastatin Simvastatin Simvastatin Simvastatin Simvastatin Simvastatin Simvastatin Simvastatin Simvastatin Simvastatin Simvastatin Simvastatin Simvastatin Simvastatin Simvastatin Simvastatin Simvastatin Simvastatin Simvastatin Simvastatin Simvastatin Simvastatin
Wikipage page ID	771982 (xsd:integer)
Wikipage revision ID	169972237 (xsd:integer)
dbo:wikiPageWikiLink	category-fr:Médicament_essentiel_listé_par_l'OMS Atherosclerosis category-fr:Delta-lactone category-fr:Ester_butanoïque category-fr:Statine Cholesterol dbpedia-fr:Chromosome_12_humain Cytochrome P450 dbpedia-fr:Enzyme dbpedia-fr:Interaction_médicamenteuse Myopathy dbpedia-fr:Organisation_mondiale_de_la_santé dbpedia-fr:Réductase Statin dbpedia-fr:Triglycéride dbpedia-fr:Tératogenèse dbpedia-fr:Maladie_cardiovasculaire
page length (characters) of wiki page	6936 (xsd:nonNegativeInteger)
EINECS number	616-751-8

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