About: dbpedia-fr:Actinomycine

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An Entity of Type : dbo:ChemicalSubstance, within Data Space : fr.dbpedia.org associated with source document(s)

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rdf:type	Thing chemical compound Chemical compound dul:ChemicalObject dbo:ChemicalSubstance
rdfs:label	Actinomycine D (fr) Actinomicina (es) Актиноміцин (uk) داكتينومايسين (ar) アクチノマイシン (ja) 放线菌素 (zh)
rdfs:comment	L’actinomycine D, ou dactinomycine (DCI), est un antibiotique peptidique isolé en 1940 à partir de bactéries du genre Streptomyces. C'est l'un des premiers antibiotiques pour lesquels on a mis en évidence des propriétés anticancéreuses et c'est l'un des plus anciens traitements chimiothérapeutiques. Elle a pour effet de bloquer la transcription de l'ADN en ARN messager par l'ARN polymérase en se fixant au voisinage du promoteur. (fr)
rdfs:seeAlso	https://www.britannica.com/science/dactinomycin https://www.britannica.com/topic/actinomycin-D https://mor.nlm.nih.gov/RxNav/search?searchBy=NUI&searchTerm=N0000146314 http://echa.europa.eu/substance-information/-/substanceinfo/100.000.058 http://tools.wmflabs.org/wikidata-externalid-url/?p=679&url_prefix=http://gestis-en.itrust.de/nxt/gateway.dll?f=id$t=default.htm$vid=gestiseng:sdbeng$id=&id=492334 https://commons.wikimedia.org/wiki/Category:Dactinomycin https://tools.wmflabs.org/magnustools/cas.php?cas=50-76-0 https://www.jstor.org/topic/actinomycin https://www.ncbi.nlm.nih.gov/sites/entrez?cmd=search&db=pccompound&term=%22RJURFGZVJUQBHK-IIXSONLDSA-N%22InChIKey http://toxnet.nlm.nih.gov/cgi-bin/sis/search2/r?dbs+hsdb:@term+@DOCNO+3220 http://www.whocc.no/atc_ddd_index/?code=L01DA01 http://www.drugbank.ca/drugs/DB00970 https://comptox.epa.gov/dashboard/DTXSID9020031 http://bioportal.bioontology.org/ontologies/RXNORM?p=classes&conceptid=3100 http://chemapps.stolaf.edu/jmol/jmol.php?&model=InChI=InChI=1S/C62H86N12O16/c1-27(2)42-59(84)73-23-17-19-36(73)57(82)69(13)25-38(75)71(15)48(29(5)6)61(86)88-33(11)44(55(80)65-42)67-53(78)35-22-21-31(9)51-46(35)64-47-40(41(63)50(77)32(10)52(47)90-51)54(79)68-45-34(12)89-62(87)49(30(7)8)72(16)39(76)26-70(14)58(83)37-20-18-24-74(37)60(85)43(28(3)4)66-56(45)81/h21-22,27-30,33-34,36-37,42-45,48-49H,17-20,23-26,63H2,1-16H3,(H,65,80)(H,66,81)(H,67,78)(H,68,79) http://chemapps.stolaf.edu/jmol/jmol.php?model=CC1C(C(=O)NC(C(=O)N2CCCC2C(=O)N(CC(=O)N(C(C(=O)O1)C(C)C)C)C)C(C)C)NC(=O)C3=C4C(=C(C=C3)C)OC5=C(C(=O)C(=C(C5=N4)C(=O)NC6C(OC(=O)C(N(C(=O)CN(C(=O)C7CCCN7C(=O)C(NC6=O)C(C)C)C)C)C(C)C)C)N)C http://fdasis.nlm.nih.gov/srs/srsdirect.jsp?regno=1CC1JFE158 http://www.simolecule.com/cdkdepict/depict/bow/svg?smi=CC@@H1C@@H(C(=O)NC@@H(C(=O)N2CCCC@H2C(=O)N(CC(=O)N(C@H(C(=O)O1)C(C)C)C)C)C(C)C)NC(=O)C3=C4C(=C(C=C3)C)OC5=C(C(=O)C(=C(C5=N4)C(=O)NC@H6C@H(OC(=O)C@@H(N(C(=O)CN(C(=O)C@@H7CCCN7C(=O)C@H(NC6=O)C(C)C)C)C)C(C)C)C)N)C&zoom=2.0&annotate=cip https://dtp.cancer.gov/dtpstandard/servlet/dwindex?searchtype=NSC&chemnameboolean=and&outputformat=html&searchlist=3053&Submit=Submit https://dtp.cancer.gov/dtpstandard/servlet/dwindex?searchtype=NSC&chemnameboolean=and&outputformat=html&searchlist=755841&Submit=Submit https://ncim-stage.nci.nih.gov/ncimbrowser/ConceptReport.jsp?dictionary=NCI%20Metathesaurus&code=C0010934 http://chemdb.niaid.nih.gov/CompoundDetails.aspx?AIDSNO=009885
sameAs	dbr:Dactinomycin dbpedia-commons:Category:Dactinomycin wikidata:Q186127 dbpedia-ar:داكتينومايسين dbpedia-cy:Dactinomycin dbpedia-de:Actinomycin_D dbpedia-es:Actinomicina dbpedia-fa:داکتینومایسین dbpedia-fi:Daktinomysiini dbpedia-ja:アクチノマイシン dbpedia-kk:Актиномицин_Д dbpedia-ko:악티노마이신 http://or.dbpedia.org/resource/ଡାକ୍ଟିନୋମାଇସିନ dbpedia-pl:Daktynomycyna dbpedia-pt:Dactinomicina dbpedia-ro:Dactinomicină dbpedia-ru:Дактиномицин dbpedia-sh:Aktinomicin dbpedia-sl:Daktinomicin dbpedia-sr:Aktinomicin dbpedia-uk:Актиноміцин dbpedia-vi:Dactinomycin dbpedia-zh:放线菌素 http://azb.dbpedia.org/resource/داکتینومایسین http://g.co/kg/m/07y3fy https://www.kegg.jp/entry/D00214 http://purl.obolibrary.org/obo/CHEBI_27666 http://id.nlm.nih.gov/mesh/D003609 http://id.nlm.nih.gov/mesh/M0005644 http://ma-graph.org/entity/2776695378 http://rdf.chemspider.com/10482167 http://rdf.ebi.ac.uk/resource/chembl/molecule/CHEMBL1554 http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID457193
Wikipage page ID	1299333 (xsd:integer)
Wikipage revision ID	152957587 (xsd:integer)
dbo:wikiPageWikiLink	category-fr:Médicament_essentiel_listé_par_l'OMS category-fr:Depsipeptide category-fr:Inhibiteur_de_la_réplication_de_l'ADN 7-Aminoactinomycin D dbpedia-fr:ARN_polymérase dbpedia-fr:Acide_désoxyribonucléique dbpedia-fr:Acide_ribonucléique_messager Hair loss Anorexia (symptom) dbpedia-fr:Antibiotique dbpedia-fr:Anticancéreux Mouth ulcer dbpedia-fr:Aplasie_médullaire Apoptosis Bacteria Molecular biology dbpedia-fr:Cancer category-fr:Agent_chimiothérapeutique category-fr:Antibiotique_polypeptidique category-fr:Azolidine category-fr:Benzamide category-fr:Cancérogène_du_groupe_3_du_CIRC category-fr:Cyclohexadiène category-fr:Cétone category-fr:Lactame category-fr:Lactone category-fr:Peptide_cyclique category-fr:Phénoxazine category-fr:Énamine Cell (biology) dbpedia-fr:Chimiothérapie

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